Correlation of Oral Antidiabetics to Creatinine Clearance Value in Type 2 Diabetes Mellitus Patients at a Public Hospital in Jakarta

  • Dini Permata Sari Fakultas Farmasi Universitas 17 Agustus 1945 Jakarta
  • Hanan Al Jabri Fakultas Farmasi, Universitas 17 Agustus 1945 Jakarta, Jakarta Utara, Indonesia

Abstract

Diabetes mellitus can cause various complications such as stroke, coronary heart disease, peripheral artery disease, retinopathy, neuropathy and nephropathy. Choosing the right drug in diabetes mellitus patients is very important because most antidiabetic drugs are excreted through the kidneys, so it is necessary to monitor creatinine clearance values as an indicator of impaired kidney function. The aim of this research is to find out the relationship between the use of oral antidiabetics and creatinine clearance values ​​in type 2 diabetes mellitus. This research is an observational analytical study with a cross-sectional data collection method on patients type 2 diabetes mellitusbetween January 2023 - December 2023 at a public hospital in Jakarta. This study obtained 39 patients, including the majority of patients who used oral anti-diabetics were women, 56.4%.The largest age was in the range 46 – 55 years at 38.5%. The most common type of drug is a combination of two drugs glimepirid + metformin as much as 35.9% and the creatinine clearance value in type 2 diabetes mellitus patients is a klirens kreatinin value < 90 mL/min/1.73m2 of 66.7%. The results of the chi-square test obtainedp=0.093. Based on the values obtained, there was no significant relationship between the use of oral antidiabetics and creatinine clearance values.

 

Downloads

Download data is not yet available.
Keywords: Diabetes mellitus, creatinine clearance, antidiabetic, nephropathy

References

Annisa, R., 2020, Gambaran Kadar Kreatinin Klirens pada Penderita Diabetes Melitus Tipe 2 yang Dirawat di Rumah Sakit. Medan: Politeknik Kesehatan Kemenkes Medan
Asociación Americana De Diabetes, 2023, Estandares Para El Cuidado De La Diabetes-2023, Diabetes Journals, 46(1): 1–298. Https://Diabetesjournals.Org/Care
Badan Penelitian dan Pengembangan Kesehatan., 2013, Laporan Hasil Riset Kesehatan Dasar (Riskesdas) Indonesia tahun 2013, Jakarta: Badan Penelitian dan Pengembangan Kesehatan Kementerian Kesehatan Republik Indonesia.
Bisset ES, Howlett SE, 2019, The biology of frailty in humans and animals: Understanding frailty and promoting translation, Aging medicine, 2(1): 27–34.
Cheung, A. K., Chang, T. I., Cushman, W. C., Furth, S. L., Hou, F. F., Ix, J. H., Knoll, G. A., Muntner, P., Pecoits-Filho, R., Sarnak, M. J., Tobe, S. W., Tomson, C. R. V., & Mann, J. F. E, 202, KDIGO, Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease, Kidney International, 99(3): S1–S87. https://doi.org/10.1016/j.kint.2020.11.003
Fatimah, R.N, 2020, Diabetes Melitus Tipe 2. J Majory, 4(5): 74-79.
Henny Syafitri, Amila, dan Juneris Aritonang., 2021, Metodologi Penelitian Kesehatan, Malang: Ahlimediapress.
Ilham Sholikhah, A., & Prawirohardjono, W., 2019, Gambaran Pola Penggunaan Metformin Terhadap Kadar Kreatinin Serum Pada Pasien Diabetes Melitus Tipe 2 Di Rumah Sakit “X”, Social Clinical Pharmacy Indonesia Journal, 4(2): 66-74.
Jamaluddin, G., Zulmansyah, & Nalapraya, W. Y., 2022, Perbandingan Efektivitas Insulin, Obat Antidiabetik Oral dan Kombinasi terhadap Kadar Gula Darah pada Pasien Rawat Jalan dengan DM Tipe 2 RSUD Al-Ihsan., Bandung Conference Series: Medical Science , 2(1), 511–516. https://proceedings.unisba.ac.id/index.php/BCSMS/article/view/1027
Jirna Nyoman I, Arjani Sri Made Ayu Ida, P. S. W. P. A. G. I., 2017, Gambaran Kadar Kreaainin Serum Pada Penderita Diabetes Melitus Tipe 2, Meditory: The Jurnal Of Medical Laboratory. 5(2): 107-117.
Kementrian Kesehatan RI., 2018, Laporan Nasional Riskesdas 2018. Jakarta: Lembaga Penerbit Badan Penelitian dan Pengembangan.
Kementerian Kesehatan RI., 2019, Pedoman Pelayanan Kefarmasian Diabetes Melitus. Jakarta: Kementerian Kesehatan Republik Indonesia, 13(1): 104–116.
Komariah, K., & Rahayu, S., 2020, Hubungan Usia, Jenis Kelamin dan Indeks Massa Tubuh dengan Kadar Gula Darah Puasa Pada Pasien Diabetes Melitus Tipe 2 Di Klinik Pratama Rawat Jalan Proklamasi, Jurnal Kesehatan Kusuma Husada, 11(1): 41–50.
Kusumawardani, N., Soerachman, R., Laksono, A. D., Indrawati, L., Sari, P., & Paramita, A., 2015, Penelitian Kualitatif di Bidang Kesehatan. Yogyakarta: PT Kanisius.
Magliano, D. J., Boyko, E. J., Balkau, B., & Al, E., 2021, IDF Diabetes Atlas IDF Diabetes Atlas,10th edition. International Diabetes Federation.
Martono, Satino., 2014, Deteksi Keparahan Fungsi Ginjal Melalui Perubahan Kritis Laju Filtrasi Glomerulus Pasien Hemodialisa, Jurnal Ners, 9(1): 43-48
Muthoharoh, A., Safitri, W. A., Pambudi, D. B., & Rahman, F., 2020, Pola Pengobatan Antidiabetik Oral Pada Pasien Diabetes Mellitus Tipe 2 Rawat Jalan Di Rsud Kajen Pekalongan. Pharmacon: Jurnal Farmasi Indonesia, 2, 29–36. Https://Doi.Org/10.23917/Pharmacon.V0i0.10841
Ningsih, S. A., Rusmini, H., Purwaningrum, R., & Zulfian, Z., 2021, Hubungan Kadar Kreatinin dengan Durasi Pengobatan HD pada Penderita Gagal Ginjal Kronik, Jurnal Ilmiah Kesehatan Sandi Husada, 10(1): 202–207. https://doi.org/10.35816/jiskh.v10i1.581
Rivandi, J., & Yonata, A., 2015, Hubungan Diabetes Melitus Dengan Kejadian Gagal Ginjal Kronik, Jurnal Majority, 4(9): 27–34.
Rukminingsih, F., & Widiastuti, M., 2021, Laju Filtrasi Glomerulus Pasien Diabetes Melitus Tipe II di Salah Satu Rumah Sakit Swasta di Kabupaten Demak. Jurnal Riset Kefarmasian Indonesia, 3(3): 152-161.
Sari DP, Maulana AM, Astiani R., 2022, Clinical Characteristics Patients Pneumonia with Diabetes Mellitus at General Hospital Jakarta, Indonesia, Journal of Drug Delivery and Therapeutics, 12(6):1-3.
Sartika, F., Purbayanti, D., & Safitri, D., 2018, Gambaran Laju Filtrasi Glomerulus Pada Penderita Diabetes Mellitus Tipe 2 Di Rsud Dr. Doris Sylvanus Palangka Raya, Jurnal Surya Medika, 3(2): 13–22. Https://Doi.Org/10.33084/Jsm.V3i2.92
Sihotang, R. C., Ramadhani, R., & Tahapary, D. L., 2018, Efikasi dan Keamanan Obat Anti Diabetik Oral pada Pasien Diabetes Melitus Tipe 2 dengan Penyakit Ginjal Kronik. Jurnal Penyakit Dalam Indonesia, 5(3): 150. https://doi.org/10.7454/jpdi.v5i3.202
Soelistijo, S., 2021, Pedoman Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 Dewasa di Indonesia 2021. Indonesia: PB. PERKENI.
Sukandar et al., 2013, Iso Farmakoterapi Buku 1 – 2, Jakarta : ISFI Penerbitan.
Published
2024-06-30
How to Cite
Sari, D., & Jabri, H. (2024). Correlation of Oral Antidiabetics to Creatinine Clearance Value in Type 2 Diabetes Mellitus Patients at a Public Hospital in Jakarta. JOPS (Journal Of Pharmacy and Science), 7(2), 17-25. https://doi.org/10.36341/jops.v7i2.4442
PDF (Bahasa Indonesia)
Abstract views: 31
downloads: 14