Analysis of Oral Albumin Use and Factors Affecting the Success of its Therapy
Abstract
Hypoalbuminemia is a risk factor for medical treatment. Albumin has been shown to be a predictor in a number of studies in various settings. Several studies examined albumin as a marker of nutritional status and its association with outcomes (eg, mortality and length of hospital stay). In critical illness, the Acute Physiology and Chronic Health Evaluation (APACHE III) risk score includes serum albumin levels and shows a strong inverse correlation between serum albumin and mortality in critically ill patients.
This research was conducted observationally to analyze the use of oral albumin and the factors that influence the success of therapy in the Lung Inpatient Room at Dr Soetomo Regional Hospital for the period 1 January – 31 October 2022. Patients diagnosed with Community Pneumonia, Lung Cancer and Lung Tuberculosis. This research was carried out by collecting secondary data via e-medical records. Data taken were patient demographic data (name, gender, weight, age, length of stay) and albumin data before and after receiving oral albumin.
From the research results, the number of samples was 87. The number of samples was 87 patients. Of the 87 patients, 66 male patients (75.86%) were 21 female patients (24.14%), the largest age range was 51 - 60 years, 21 patients (24.14%). The highest body weight ranged from 61-70 kg for 50 patients (57.47%), the longest length of stay ( Length of Stay ) was 10-20 days for 45 patients (51.72%). The most common primary diagnosis was new tuberculosis in 42 patients (48.28%). The highest use of oral albumin was more than 100 capsules, as many as 20 patients (22.99%) with the highest duration of use being 10-19 days, namely 38 patients (43.68%). The statistical results show that there is no significant difference between before receiving oral albumin and after receiving oral albumin with a value of P = 0.541. Factors that influence the success of oral albumin therapy are length of stay with a value of P = 0.001 *
Keywords: Oral albumin, pulmonary tuberculosis, lung cancer, pneumonia, length of stay
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References
Akirov A, Masri-Iraqi H, Atamna A, Shimon l. Low Albumin Levels Are Associated with Mortality Risk in Hospitalized Patients. Am J Med. 2017;130(12):1465.
Arques, S., and Ambrosi, P., 2011, Human Albumin in the Clinical Syndrome of Heart Failure, Journal of Cardiac Failure, 17 (6): 451 - 458 Boldt, J., 2010, Use of Albumin: an Update, British Journal of Anaesthesia, 104 (3): 276– 284
Asfar, M., Abu BT, Nurlailah A., Meta M. 2014, Extraction of Albumin of Snakehead Fish (Channa Stiratus) In Producing The Fish Protein Concentrate (FPC), International Journal of Scientific & Technology Research, 3(4): 85-88.
Benedict, S., Tarver-Carr. ME, Powe, NR, Eberhardtm, MS, Brancati, FL 2003. Lifestyle Factors, Obesity and the Risk of Chronic Kidney Disease . Epidemiology. Vol 14. No. 4, July 2003.
Boldt, J., 2010, Use of Albumin: an Update, British Journal of Anaesthesia, 104 (3): 276– 284.
Dwijayanti, DR, Muhammad SD, Muhaimin R. 2016, The Role of VipAlbumin As An Immunostimulatory Agent For Controlling Homeostasis and Proliferation of Lymphoid Cells, Central European Journal of Immunology, 41(1):31-38. doi: 10.5114/ceji.2016.58814
Don, BR; Kaysen, G. Serum albumin: Relationship to inflammation and nutrition. Semin. Dial . 2004, 17 , 432–437
Espinosa E, Feliu J, Zamora P, Baron MG, Sanchez JJ, Ordonez A, et al. Serum-Albumin and Other Prognostic Factors Related to Response and Survival in Patients with Advanced Nonsmall Cell Lung-Cancer. Lung Cancer. 1995; 12(1-2) :67–76
Fadhilah, TM, & Sari, EM (2021). The effectiveness of cork fish (channa striatus) and egg white snack to improve blood albumin level and body weight in tuberculosis patients. College Journal of Nutrition, 10(4), 251–256. Retrieved from http://ejournal3.undip.ac.id/index.php/jnc/
Gounden V, Vashisht R, Jialal I. Hypoalbuminemia. Treasure Island (FL): StatPearls Publishing. 20 May 2020. http://www.ncbi.nlm.nih.gov/books/ .
Herumuryawan, M., & Hardaningsih, G. (2017). Effect of Striped Snakehead fish (ophiocephalusstriatus) extract supplement pills compared to human albumin infusion on Serum Albumin, Lipid Profile, Malondialdehyde and IL-8 serum levels on Nephrotic Syndrome. PJMHS, 11(4), 1601–1606.
Hsu HY, Hwang LC, Lin CH, Lin CJ, Tjung JJ. Impact of Serum Albumin on Functional Status and Hospital Outcome in Oldest-Old Inpatients. International Journal of Gerontology. 2015;9:1-3.
Howard S. Oster, at al, J. Clin. Med. Serum Hypoalbuminemia Is a Long-Term Prognostic Marker in Medical Hospitalized Patients, Irrespective of the Underlying Disease, 2022, 11 (5), 1207; https://doi.org/10.3390/jcm11051207 /
Igarashi, T. Pediatric fanconi syndrome. In Pediatric Nephrology ; Avner, E.D., Harmon, W.E., Niaudet, P., Yoshikawa, N., Emma, F., Goldstein, S.L., Eds.; Springer: Berlin/Heidelberg, Germany, 2016; pp. 1355–1388.
Decree of the Minister of Health HK.01.07/Menkes/1438/2023 concerning National Guidelines for Medical Services for Lung Cancer Management
Decree of the Minister of Health HK.01.07/Menkes/2147/2023 concerning National Guidelines for Medical Services for the Management of Pneumonia in Adults
Knaus, WA; Wagner, D.P.; Draper, EA; Zimmerman, J.E.; Bergner, M.; Bastos, P.G.; Sirio, CA; Murphy, DJ; Lotring, T.; Damiano, A.; et al. The APACHE III prognostic system. Risk prediction of hospital mortality for critically ill hospitalized adults. Chest 1991 , 100 , 1619–1636.
Kurniwan W, Rumende CM, Harimurti K. Hypoalbuminemia in Elderly Patients with Community-Based Pneumonia: Prevalence and Effect on Survival. Journal Indonesian Internal Medicine. 2014;1(2):79-88.
Mulyana R, Setiati S, Martini RD, Hrimurti K, Dwimartutie N. The Effect of Ophiocephalus stratius Extract on the Level of IGF-1 and Albumin in Elderly Patients with Hypoalbuminemia. Acta Med Indonesia – Indonesia J Intern Med. 2017;49(4):324-329.
Nugroho, YA 2016, Comparison of the Effectiveness of Pure Snakehead Fish Extract Albumin Therapy Compared with 20% Human Albumin on Albumin Levels and Blood pH in Hypoalbuminemia Patients, Thesis, Sebelas Maret University Postgraduate Program, Surakarta.
National Guidelines for Tuberculosis Management, Ministry of Health of the Republic of Indonesia, 2020
Puspita, E., Christianto, E., Yovi, I. 2016. Description of nutritional status in pulmonary TB patients undergoing outpatient treatment at Achmad Hospital Pekanbaru. JOM FK, vol. 3 no. 2.
Pratt, DS Evaluation of Liver Function. In Harrison's Principles of Internal Medicine ; Jameson, JL, Fauci, AS, Kasper, DL, Hauser, SL, Longo, DL, Loscalzo, J., Eds.; McGraw-Hill Education: New York, NY, USA, 2018.
Daughter TD, Mongan AE, Memah MF. Description of Serum Albumin Levels in Patients Chronic Kidney Disease Stage 5 Non Dialysis. Journal of e-Biomedics (eBm). 2016;4(1):173-177.
Radjatadoe, YP, Suwondo, A., & Sumarni, S. (2021). The Effect of Giving Fish Products on Albumin Levels, Mid Upper Arm Circumference, Body Mass Index: (Systematic Literature Review). EAS Journal of Nutrition and Food Sciences, 3(1), 1–5. Doi:10.36349/easjnfs.2021.v03i01.001
RSU Dr Soetomo, 2003, Guidelines for Using Albumin Infusion, 2 nd ed, RSU Dr. Soetomo, Surabaya
Tedja, VR (2012). The relationship between individual, socio-demographic and administrative factors and the length of stay for inpatients at Pantai Indah Kapuk Hospital in 2011. University of Indonesia . http://S3.amazonaws.com/academia.edu. Accessed January 20 2017
Watanabe, H.; Maruyama, T. Albumin as a Biomarker. In Albumin in Medicine: Pathological and Clinical Applications ; Otagiri, M., Chuang, VTG, Eds.; Springer: Singapore, 2016; pp. 51–69.
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